This review will discuss the role of Hh signaling in AML pathogenesis, describe the preclinical and clinical development of Hh pathway inhibitors for the treatment of AML, and examine the current
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In the lungs, mucus plays a key role in protecting your lungs and airways from harmful irritants. Sputum and phlegm are other names sometimes used to refer to the mucus in your lungs
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Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during embryonic development. Recently, uncontrolled activation of this pathway has been demonstrated in various
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Airway mucus traps inhaled toxins and transports them out of the lungs by means of ciliary beating and cough (Fig. 1).
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Hedgehog pathway inhibitors, also sometimes called hedgehog inhibitors, are small molecules that inhibit the activity of a component of the Hedgehog signaling pathway.
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Hedgehog inhibitors represent a class of targeted therapy drugs primarily used in oncology. These medications function by obstructing a specific cellular communication pathway that,
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The Hedgehog (Hh) signalling pathway is the major pathway associated with the formation of basal carcinoma tumorigenesis, thus, targeting this is a promising therapeutic approach. Some Hh
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